De wonderen zijn de wereld niet uit! Leef langer en gezonder met de supplementen van David Sinclair.
Ontdek AEON™ van Perpetua.Life, geïnspireerd door de baanbrekende inzichten van Dr. David Sinclair, een vooraanstaand professor in de genetica aan Harvard Medical School en president van de Academy for Health and Lifespan Research. Dr. Sinclair, bekend om zijn onderzoek naar veroudering en hoe we de effecten ervan kunnen vertragen, heeft significante bijdragen geleverd aan ons begrip van het verouderingsproces.
AEON™, een anti-verouderingssupplement, belichaamt deze inzichten door een unieke 11-componenten complex aan te bieden dat zich richt op verschillende aspecten van veroudering, zoals oxidatieve stress en telomeerverkorting. Recente studies tonen aan dat deze componenten, wanneer dagelijks genomen, de levensduur bij muizen en primaten met tot 30% kunnen verlengen, met veelbelovende studies bij mensen die momenteel gaande zijn.
De wetenschap achter AEON™ is diep geworteld in Dr. Sinclair's onderzoek, dat de rol van NAD+ biosynthese in de regulatie van de levensduur en het belang van sirtuïnes, geactiveerd door caloriebeperking bij zoogdieren, heeft aangetoond. Deze ontdekkingen hebben geleid tot de ontwikkeling van kleine moleculen die SIRT1 activeren, zoals resveratrol, en onderzoeken hoe plantenstressmetabolieten zoals polyfenolen de verdedigingen tegen veroudering activeren.
Dr. Sinclair's lab heeft ook onderzoek gedaan naar de rol van mitochondriën in veroudering en ziekte, waarbij is ontdekt dat asynchronie tussen de nucleaire en mitochondriale genomen tijdens het verouderen een belangrijke rol speelt. Dit heeft geleid tot de "Mitochondrial Oasis Hypothesis", waarbij NAD+-niveaus in mitochondriën van cruciaal belang zijn voor celoverleving.
Daarnaast richt het onderzoek van Dr. Sinclair zich op het herprogrammeren van cellen om hun epigenetische status te resetten en hun leeftijd om te keren, met een focus op zenuwregeneratie en het omkeren van andere verouderingssymptomen. Dit baanbrekende werk biedt nieuwe inzichten en mogelijkheden voor de behandeling van verouderingsgerelateerde aandoeningen, zoals type 2 diabetes, Alzheimer, hart- en vaatziekten en kanker.
Met AEON™ van Orihreba, gebaseerd op de revolutionaire inzichten van Dr. Sinclair, kunt u een stap zetten naar een langer en gezonder leven, ondersteund door de meest geavanceerde wetenschap in de strijd tegen veroudering.
Don’t settle for a single ingredient to support healthy aging. AEON™ is the only product to offer an 11-compound longevity complex that addresses everything from oxidative stress, glycation, telomere shortening, to side reactions, and mutations [*]. New studies show each of these compounds when taken daily extend life in mice & primates up to 30% [*]. Promising studies in humans are currently underway. Furthermore, a synergistic effect happens when they're compounded that has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death [*]. Below we'll break down the origin, and effects of each ingredient in AEON™ with links to independent, peer-reviewed studies.
Nicotinamide DUO™
Nicotinamide DUO™ is a proprietary NAD+ precursor developed by Perpetua.Life® Biotech based on a an 80/20 blend of Mono/Riboside (LNR) which has been found to boost NAD+ level even higher than Riboside alone. NAD+ is a compound found in every cell in your body and involved in many critical processes, including energy metabolism, DNA repair, and gene expression (22, 23). NAD+ levels decline with age, and this decline is thought to be associated with accelerated physical decline and the onset of age-related diseases like Alzheimer’s (23). Studies have shown that supplementing with NAD+ precursors like NR restores NAD+ levels and prevents age-related physical decline (24) For example, a study in aging subjects demonstrated that supplementing orally with Nicotinamide Mono prevented age-associated genetic changes and improved energy metabolism, physical activity, and insulin sensitivity (24B). A 2019 study in 12 men with an average age of 75 showed that supplementing with up to 1 gram of Nicotinamide daily for 21 days increased NAD+ levels in skeletal muscle and reduced levels of inflammatory proteins in the body (25).
Fisetin
Fisetin is a flavonoid compound that’s considered a senotherapeutic, meaning it can kill senescent cells. Fisetin as an anticancer agent targeting the growth signaling pathways (F01). Fisetin and Its Role in Chronic Diseases (F02). Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy (F03). Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (F03). Rodent studies suggest that it may reduce the number of senescent cells in tissues and extend lifespan (41). Fisetin: a dietary antioxidant for health promotion (F04) Exploring the molecular targets of dietary flavonoid fisetin in cancer (F05).
Quercetin
Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine. Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar, and help prevent heart disease (Q1). Quercetin in cancer prevention and therapy (Q2). Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (F03). Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer (Q3). A preliminary investigation demonstrating the effect of quercetin on the expression of genes related to cell-cycle arrest, apoptosis and xenobiotic metabolism in human CO115 colon-adenocarcinoma cells using DNA microarray (Q4). Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Resveratrol
Resveratrol is a polyphenol in grapes, berries, peanuts, and red wine that may promote longevity by activating certain genes called sirtuins. It has been shown to increase the lifespan of fruit flies, yeasts, and nematodes (42). Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging (R4) Resveratrol, an Nrf2 activator, alleviates aging-related progressive renal injury (R3) Role of resveratrol in regulation of cellular defense systems against oxidative stress (R2). Effect of resveratrol and pterostilbene on aging and longevity (R1). Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a periodontitis model (R5). Quercetin, caffeic acid and Resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells (Q4).
Astragalus
Astragalus membranaceus is a stress-reducing herb used in traditional Chinese medicine. It may help combat aging by reducing oxidative stress, promoting immune function, and preventing cellular damage (40). Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro (A2). Astragalus membranaceus: A Review of its Protection Against Inflammation and Gastrointestinal Cancers (A1). Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives with astragalus (A3). Experimental and clinical studies of mechanisms of the anti-aging effects of chemical compounds in Astragalus membranaceus (A4). Astragalus (a traditional Chinese medicine) for treating chronic kidney disease (A5).
Epigallocatechin Gallate (EGCG)
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease (9, 10, 11). Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development. EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK). It also induces autophagy, the process by which your body removes damaged cellular material (12). EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13, 14, 15).
Epigallocatechin Gallate (EGCG)
Epigallocatechin gallate (EGCG) is a well-known polyphenol compound concentrated in green tea. It offers impressive health benefits, with research supporting its use to reduce the risk of certain cancers, as well as other health conditions like heart disease (9, 10, 11). Among EGCG’s diverse array of potential health-promoting properties is its ability to promote longevity and protect against age-related disease development. EGCG may slow aging by restoring mitochondrial function in cells and acting on pathways involved in aging, including the AMP-activated protein kinase signaling pathway (AMPK). It also induces autophagy, the process by which your body removes damaged cellular material (12). EGCG intake has been associated with a reduced risk of all-cause mortality, diabetes, stroke, and heart-disease-related death. Plus, animal studies have shown that it can protect against skin aging and wrinkles caused by ultraviolet (UV) light (13, 14, 15).
L-Theanine
L-theanine is an amino acid concentrated in certain teas, including green tea. It may help protect against mental decline and has been shown to extend the lifespan of roundworms by around 5% (35, 36). l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation (T1). Protective Effect and Mechanism of Theanine on Lipopolysaccharide-Induced Inflammation and Acute Liver Injury (T2). L-Theanine extends lifespan of adult Caenorhabditis elegans (T3). The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent (T4). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry
(T5).
